ANTI-MULLERIAN HORMONE AND OVARIAN RESERVE DISPARITY AMONG WOMEN OF THREE DIFFERENT ETHNIC GROUPS IN THE NIGER DELTA REGION, NIGERIA
Keywords:
Anti-Mullerian Hormone (AMH), Ethnicity, Ovarian Reserve, InfertilityAbstract
Background: Increasing research indicates that reproductive function and potential may vary among racial and ethnic groups. Timing of puberty, infertility, and reproductive aging have all been shown to vary. Anti-mullerian hormone (AMH) levels are one of the novel diagnostic biomarkers for ovarian reserve. Ethnic variations in anti-Mullerian hormone (AMH) levels may influence fertility outcomes. Aims: This cross-sectional study evaluated the difference in ovarian reserve marker (anti-mullerian hormone) in women from three ethnic groups (Ikwerre, Kalabari and Ijaws) in Niger Delta Region, Nigeria. Materials/Method: For the purpose of the study, a total of 1,773 women in good health were used, including 580 from Ikwerre tribe, 593 from Kalabari tribe, and 600 from Ijaws tribes. Four age groups of the women were created; 20-30, 31-40, 41-50 and 51-60 years old. After completing the questionnaire with questions about age, tribe, last menstrual date, and whether or not they were taking medication for infertility problems, the women were chosen at random. Blood serums were collected from the women and Enzyme Linked Immunoassay method was used to analyze serum level of Anti-Mullerian Hormone. Results: The result obtained revealed that Anti-Mullerian Hormone levels were significantly higher amongst Kalabari women, and significantly lower amongst the Ikwerre women compared to the other tribes. The result also showed that that ovarian reserve significantly decreases with age. However, the negative correlation of Anti-Mullerian Hormone with age was stronger among women of the Ijaw tribes, suggesting that the Ijaw women have a longer reproductive age compared to the other tribes. Conclusions: This study has established that different tribes exhibit significant Anti-Mullerian Hormone levels at different age group, with the Kalabari Women having the highest AMH levels, and Ikwerre women having the lowest Anti-Mullerian Hormone levels in all age groups. Ethnicity may play significant role in ovarian reserve, and therefore, it should be considered during patient counselling and personalized management.
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